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NeuroprotectionAnti-inflammatoryTissue Repair

ARA-290

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Also known as: Cibinetide, Helix B Surface Peptide

Overview

ARA-290 (Cibinetide) is a synthetic 11-amino acid peptide derived from erythropoietin (EPO). It provides tissue-protective and anti-inflammatory effects without stimulating red blood cell production, making it safer than EPO for regenerative applications.

How It Works

ARA-290 selectively activates the innate repair receptor (IRR), a heterodimer of the EPO receptor and β-common receptor (CD131). This triggers tissue-protective signaling without stimulating red blood cell production, providing the regenerative benefits of EPO safely.

Research Status

Phase 2/3 clinical trials for neuropathy. Orphan drug designation for sarcoidosis. Not yet FDA approved.