Overview
Tesamorelin is a synthetic 44-amino acid GHRH (Growth Hormone Releasing Hormone) analog with enhanced stability. It is the only FDA-approved peptide for reducing visceral adipose tissue, originally developed for HIV-associated lipodystrophy.
How It Works
Tesamorelin activates GHRH receptors in the pituitary gland, stimulating the synthesis and pulsatile release of natural growth hormone. This increases IGF-1 levels, which promotes lipolysis in visceral fat tissue while preserving or building muscle.
Research Status
FDA approved in 2010 (Egrifta). Extensive clinical trials with over 800 participants. Gold standard for GHRH therapy.
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CJC-1295 is a synthetic growth hormone-releasing hormone (GHRH) analog that increases growth hormone and IGF-1 levels. Available with or without DAC (Drug Affinity Complex) for different release profiles.
Sermorelin
Sermorelin is a growth hormone-releasing hormone (GHRH) analog that stimulates the pituitary gland to naturally produce more growth hormone. It's considered safer than direct HGH supplementation.
Ipamorelin
Ipamorelin is a selective growth hormone secretagogue that stimulates the pituitary gland to release growth hormone without significantly affecting other hormones like cortisol or prolactin.