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Estrogen

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Also known as: Estradiol, E2, 17β-Estradiol, Estrace

Overview

Estrogen (primarily estradiol) is a key hormone for both women and men. In women, it regulates the menstrual cycle and supports bone health. In men, optimal estrogen levels are crucial for libido, joint health, and cardiovascular function.

How It Works

Estrogen binds to estrogen receptors (ERα and ERβ) throughout the body, influencing gene expression in bones, brain, heart, and reproductive tissues. It regulates cholesterol, promotes vasodilation, and supports neuroplasticity.

Research Status

FDA approved for menopause and various conditions. Decades of clinical research supporting benefits with proper monitoring.